Christoph Hufeland, a true example of a holistic physician and father of many of our nature cures credited agents of the vital power " which are capable of exciting, invigorating, and, in great probability, of affording subtle nourishment. These , in particular are heat, light, air, or rather oxygen; three celestial gifts, which with great propriety may be called the friend and guardian spirits of life".

Around the same time period, Samuel Hahnemann was so disillusioned with the state of medical practice of the time he stopped practicing and began translating old medical texts. In this, he discovered and later established the roots of homeopathy. Through numerous experiments conducted over several years, Hahnemann illustrated that any medicine will cure a particular disease if it is capable of producing symptoms in healthy individuals which are similar to the overall experience of a disease in one who is sick.